PhD position in Time-Resolved Crystallography of Enzymes (STRIDE project) — synchrotron-based s[...]

PhD position in Time-Resolved Crystallography of Enzymes (STRIDE project)

We invite applicants for an externally‑funded three‑year PhD fellowship within structural enzymology and time‑resolved crystallography. The STRIDE project (Synchrotron‑based Time‑Resolved crystallographic Investigations of Dynamic states in Esterase catalysis via novel analogues) is funded by the Novo Nordisk Foundation as a MicroMAX Collaborative Research Grant, in collaboration with the University of Gothenburg and Chalmers University of Technology.

Start date: 1 January 2027 (or as soon as possible thereafter)

The PhD candidate will be based at the University of Copenhagen (UCPH) and supervised by Prof. Leila Lo Leggio. The project has two closely connected strands:

• 1) Synthesis and evaluation of novel substrate analogues for esterases, including slowly cleavable and photoswitchable compounds.
• 2) Static single‑crystal and serial‑synchrotro...